Effect of Atorvastatin on expression of HIF-1α,VEGF in hypertrophic myocardium of rat

Aim:To detect the expression of hypoxia inducible factor-1a (HIF-1α) and vascular endothelial growth factor (VEGF) and the effect of Atorvastatin on them in hypertrophic myocardium rat.Methods:33 male Wistar rats were randomly divided into sham-operated group(n=10),model group (n=13) and Atorvastatin group (n=10). The rats of model group and Atorvastatin group were made to be myocardial hypertrophy model produced by abdominal aortic banding. 24 h after operation,the rats of Atorvastatin group were given a daily dose of 10 mg/kg of Atorvastatin by gastric gavage,and distilled water were given to the other two groups,respectively. After 6 weeks,the extent of hypertrophic myocardium,hemodynamic performance,and the expressions of HIF-1α and VEGF in myocardium were determined.Results:Compared with those of sham-operated group,the left ventricular hypertrophy(LVH),the expressions of HIF-1α and VEGF of the model group were higher (P0.05).The extent of LVH in Atorvastatin group was significantly lower compared with that of the model group(P0.05),and there were no significantly differences in the expressions of HIF-1α and VEGF between model group and Atorvastatin group(P0.05).Conclusion:Atorvastatin obviously attenuates the development of myocardial hypertrophy,which can't depend on the expression of HIF-1α.