Pseudomonas aeruginosa and Its Clinical and Drug Resistance Investigation

OBJECTIVE To investigate the clinical characteristics of Pseudomonas aeruginosa infection and drug resistance and provide guidance for clinical use.METHODS Retrospective survey was taken to get the distribution of P.aeruginosa in our hospital from Jan 2004 to Dec 2007;disc diffusion method was used to detect the susceptibility of 234 P.aeruginosa strains against ciprofloxacin,ceftazidime,ceftriaxone,amikacin,imipenem and meropenem and agar dilution method was used to detect the minimum inhibitory concentration(MIC) of imipenem and meropenem.RESULTS 76.6% of P.aeruginosa were isolated from respiratory tract specimens which were sent from ICU and neurosurgery department.The strains isolated from 2005 were higher resistant to more antibiotics than isolated from other time,The P.aeruginosa was higher susceptible to ceftazidime and amikacin.The MIC of imipenem and meropenem showed significant difference.CONCLUSIONS The infection rate of P.aeruginosa is high and shows multiple antibacterial resistance.Imipenem had higher drug resistance than meropenem to P.aeruginosa.