Efficacy and Safety of Citalopram Combined with Buspirone in Treatment of Patients with Post-stroke Depression

Objective:To explore efficacy and safety of citalopram combined with buspirone in treatment of patients with post-stroke depression.Methods:Sixty patients with post-stroke depression were randomly assigned to study group(treated with citalopram combined with buspirone)and control group(treated with citalopram alone)for 8 weeks(each group having 30 cases).Hamilton Depressive Scale(HAMD),Chinese Stroke Scale(CSS),Activity of Daily Living Scale(ADL)and Treatment Emergent Side effect Scale(TESS)were used to evaluate the efficacy and adverse effect respectively.Results:After 8 weeks,the apparent effective ratio and the scores of ADL in study group were significantly higher than those in control group.The scores of HAMD in study group were lower significantly than those in control group after 4 weeks.CSS and ADL were markedly improved in two groups after treatment.The incidence of adverse effect and the scores of TESS and CSS had no significant difference between the two groups.Conclusion:Citalopram combined with buspirone is more effective than citalopram alone in treatment of post-stroke depression.It is the same safe as the latter.