Losartan in treating proteinuria of chronic glomerulonephritis

AIM: To compare the influence of losartan with that of benazepril on chronic glomerulonephritis hypertension, proteinuria and renal function. METHODS: Sixty six patients with chronic glomerulonephritis were divided into two groups: thirty four patients in losartan treatment group (M 19, F 15; age 40 a± s 13 a), thirty two patients in benazepril control group (M 14, F 18; age 38 a±15 a). At the base of using antilipemic agents and anticoagulant in both groups, losartan 50 mg, po , qd or benazepril 10 mg, po , qd was added. Four weeks later, hydrochlorothiazide 12.5-25 mg, po , qd were added to the patients with diastolic blood pressure≥11.3 kPa. The whole treatment period was 24 wk. RESULTS:After 24 wk treatment the number of patients up to objective value of blood pressure was 47 % and 50 %( P 0.01) in two groups. The decrease of proteinuria was 1.9 g·24 h -1 ±1.1 g·24 h -1 and 1.7 g·24 h -1 ±1.3 g·24 h -1 ( P 0.01). The serum creatinine maintained steady state ( P 0.05 ). The occurance rate of adverse reactions such as cough was 6 % in losartan group while 26 % in benazepril group. CONCLUSION:Similar to benazepril, losartan has the effect of decreasing proteinuria and renoprotection with fewer adverse reactions.