The Relations between serum uric acid levels and renal injury in hypertension patients

Objective To study the relations between level of serum uric acid(UA) and extent of renal injury in hypertension patients.Methods The 126 patient with hypertension were selected at random, and divided into three groups: hypertension group without renal injury(n=58), hypertension group with early renal injury(n=41) and hypertension group with clinical renal injury(n=27);the 67 subjects with normal blood pressure were selected as control group. Their levels of serum UA, creatinine(Cr), urea, urine micro-albumin (m-Alb) and urine N-acetyl-β-D-glucosaminidase(NAG) were measured.Results The levels of UA of 126 hypertension patients were 334.7±96.0μmol/L and those of 67 subjects of control group were 226.4±54.6μmol/L. The difference between them was significant(t=8.526,P0.001). The incidence of hyperuricemia in hypertension group and control group were 24.60% and 2.98% respectively. The difference between them was significant(χ2=14.42,P0.01). The levels of UA in hypertension group with early renal injury and hypertension group without renal injury were 325.5±87.4μmol/L and 323.4±85.9μmol/L respectively. The difference between them was not significant (t=0.119,P0.05). The levels of UA(372.8±117.8μmol/L) in hypertension group with clinical renal injury were higher obviously than those in hypertension group without renal injury and the difference between them was significant(t=2.165,P0.05). Positive correlation was shown between serum UA and urine m-Alb and serum urea(r=0.209?0.593,P0.05,P0.01). Conclusion There are some relations between the level of serum UA and the extent of renal injury. Hypertension with renal injury is a factor in level increase of serum UA.