Application of Midzolam with Fentanyl in Colonoscopy

Objective To investigate the sedative and analgesic effect of midzolam with fentanyl in colonoscopy. Methods One hundred and forty-five patients with ASA of grade Ⅰ~Ⅱ to be examined by colonoscopy were randomly divided into group A (n=70) and group B (n=75). The patients in the group A were examined by traditional colonoscopy while patients in the group B were intravenously given midazolam (0.05 mg/kg) and fentanyl (1 μg/kg), 1~2 min before the colonoscopy. Nursing support was given before, during and after the operation.Results There were significant differences in the MAP and HR 1、5、10、15 min after the colonoscopy (P0.01 for both). In group B, MAP 1 min after the examination was significantly lower than that before the medication (P0.05). The incidence of respiratory inhibition was 4.00%. 92.00% of the patients had score of 2~3 on Ramsay scale for sedation, which was better than that of group A (P0.01). The results of group B, in terms of sedation, analgesia, forgetting, satisfaction and the willingness to receive another colonoscopy, were all better than those of group A (P0.01 for all). Conclusion Use of midazolam with fentanyl can achieve good sedative and analgestic effects in colonoscopy and is safe and effective. Nursing support can ensure an uneventful colonoscopic examination.