Clinical study of continuous venous infusion of low-dose 5-Fu and cisplatin combined with weekly docetaxel for treatment of advanced gastric cancer

Objective: To evaluate the efficacy and toxicity of continuous venous infusion of low-dose 5-Fluorouracil(5-Fu) and cisplatin(DDP)combined weekly docetaxel(DOC)in advanced gastric cancer.Methods:Total of 60 cases with advanced gastric cancer were included in the study.For group A(30 cases),the regimen of FPD was consisted of 5-Fu 200mg.m-2.d-1,civ,DDP 6 mg.m-2.d-1,iv gtt,5 day every week,and docetaxel 25 mg.m-2.w-1,iv gtt,which were used for 3 weeks.For group B(30 cases),was treated with continous venous infusion of low-dose 5-Fu and cisplatin(FP) regimen.The same schedule for both groups was repeated every 28 days,with two cycles for all patients.The evaluation of disease status was made after two cycles.Results: The recent response rates of group A and group B were 73.3%(22/30) and 63.3%(19/30),respectively.The median time to progression(TTP) was 4.8 months for group A and 2.6 months for group B.The median survival was 9 months for group A and 5 months for group B.The main toxicity of group A was hematological: GradeⅢ/Ⅳ leukopeniawas 13.3%(4/30).The non-hematological toxicity of group A was gastrointestinal tract reaction and alopecia.The main toxicity of group B was mild luekopenia and gastrointestinal.No severe side effects occurred in any of the cases.Concliusion: FPD regimen mentioned above was a considerable regimen for patients with advanced gastric cancer.