Clinical Analysis of Late-onset Neonatal Community Acquired Sepsis Caused by Gram-positive and Gram-negative Bacteria

Objective: To explore the clinical characteristics of late-onset neonatal community acquired sepsis caused by gram-positive and gram-negative bacteria and the drug susceptibility.Method: Collected the clinical data of 83 cases of late-onset neonatal community acquired sepsis,which were hospitalized between January 2009 and December 2012 in our hospital,and were caused by gram-positive and gram-negative bacteria.Result: There were 53 cases( 63.9%) caused by gram positive bacteria in 83 cases,mainly the coagulase negative staphylococcus and staphylococcus aureus,another 30 cases( 36.1%) were caused by gram negative bacteria,primary the e.coli.The gram positive bacteria had the lowest sensitivity to erythromycin,penicillin,and were partially sensitive to levofloxacin,gentamycin,and tetracycline,but were highly sensitive to vancomycin.The gram-negative bacteria detected had a lower sensitivity to cefalotin and ampicillin,and were partially sensitive to cephalosporin,ceftriaxone,ciprofloxacin and gentamycin,but were highly sensitive to meropenem.Gram-positive bacteria mostly infected full term infants,and gram-negative bacteria infection mainly happened in premature infants,there was no statistical difference in perinatal situation of the two groups,and were lack of specificity in clinical manifestations.Navel infection usually resulted in grampositive bacteria septicemia.PLT decreased often in gram-negative bacteria sepsis,but there was no difference in WBC,I /T and CRP.Conclusion: Late-onset neonatal community acquired sepsis are lack of specificity in clinical manifestations,early diagnosis should be combined with the gestational age,the most commonly infected site,and changes of the nonspecific index,application of antibiotics should be according to the results of drug susceptibility.