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Research on in vitro Dissolution of Different Particle Sizes of Saposhnikovia divaricata Powder

Cai Guang-xian

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Abstract

OBJECTIVE: To investigate the characteristics and regularity of in vitro dissolution of different particle sizes of Saposhnikovia divaricata powder. METHODS: Using paddle method, in vitro dissolution and dissolution kinetics of macrotin glyocoside, cimitin, 5-O-methylvysemaishamy glyocoside and haikayaphenol glyocoside were investigated, and the dissolution kinetics was simulated using Weibull equation. RESULTS: There was significant difference in the dissolution amount of effective component of different particle sizes of S. divaricata powder(P0.05). With the decrease of the particle size, dissolution rate and amount of effective component were increased. CONCLUSION: The dissolution rate and amount of effective component of S. divaricata micron powder are better than those of S. divaricata fine powder. The dissolution amount of micron powder is increased with the decrease of particle size.

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What this paper is about

OBJECTIVE: To investigate the characteristics and regularity of in vitro dissolution of different particle sizes of Saposhnikovia divaricata powder. METHODS: Using paddle method, in vitro dissolution and dissolution kinetics of macrotin glyocoside, cimitin, 5-O-methylvysemaishamy glyocoside and haikayaphenol glyocoside were investigated, and the dissolution kinetics was simulated using Weibull equation. RESULTS: There was significant difference in the dissolution amount of effective component of different particle sizes of S. divaricata powder(P0.05). With the decrease of the particle size, dissolution rate and amount of effective component were increased. CONCLUSION: The dissolution rate and amount of effective component of S. divaricata micron powder are better than those of S. divaricata fine powder. The dissolution amount of micron powder is increased with the decrease of particle size.

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Available abstract

OBJECTIVE: To investigate the characteristics and regularity of in vitro dissolution of different particle sizes of Saposhnikovia divaricata powder. METHODS: Using paddle method, in vitro dissolution and dissolution kinetics of macrotin glyocoside, cimitin, 5-O-methylvysemaishamy glyocoside and haikayaphenol glyocoside were investigated, and the dissolution kinetics was simulated using Weibull equation. RESULTS: There was significant difference in the dissolution amount of effective component of different particle sizes of S. divaricata powder(P0.05). With the decrease of the particle size, dissolution rate and amount of effective component were increased. CONCLUSION: The dissolution rate and amount of effective component of S. divaricata micron powder are better than those of S. divaricata fine powder. The dissolution amount of micron powder is increased with the decrease of particle size.

Key concepts: Dissolution, Particle size, Kinetics, Particle (ecology), Materials science, Nuclear chemistry, Chemistry, Chemical engineering

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