The clinical observation of simvastatin on lipid profile in patients with rheumatoid arthritis

Objective:To observe the effection of simvastatin on lipid profile in patients with rheumatoid arthritis and its safety.Methods:From 2010 January to 2012 November in the hospital and outpatient department of rheumatism,60 RA patients were randomly divided into A and B two groups,each group of 30 cases.The A group conbined with methotrexate,sulfasalazine,hydroxychloroquine sulfate for the treatment of RA,B group,based on A group’s treatment,were added on simvastatin.Some index were observed in two group before treatment and 6 months after treatment,cholesterol(TC),low density lipoprotein cholesterol(LDL-C),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),swelling index,joint pain index,time of morning stiffness,C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),DAS28.While the patient in the two group therapy during the occurrence of adverse reactions were statistically analyzed.Results:After 6 months treatment,TC,TG,LDL-C,both in two groups of patients,were lower than that before treatment,and HDL-C higher than that before treatment,there were significant differences(P0.05 or P0.01),after 6 months of treatment,DAS28,ESR,CRP,joint tenderness,joint swelling and morning stiffness time,both in two groups RA patients.Compared with before treatment significantly reduced,there were a very significant difference(P0.05 or P0.01).But the therapeutic effects of group B were better than those of group A(P0.05 or P0.01).The two group of patients had adverse reactions,mainly gastrointestinal discomfort and skin itching.Adverse events rates of the two groups had no significant difference(P0.05).Conclusion:RA patients have abnormal blood lipid levels,simvastatin has a direct effect on the treatment of rheumatoid arthritis.