Trabeculectomy combined with mitomycin-C in treating 98 cases of refractory glaucoma

Objective To investigate the clinical effect of compound trabeculectomy combined with mitomycin-C in treating of refractory glaucoma.Methods 90 patients(98 eyes) were randomly assigned to receive trabeculectomy with or without mitomycin-C.The observes group(46 patients with 50 eyes) underwent trabeculectomy combined with mitomycin-C. The control group(44 patients with 48 eyes) underwent conventional trabeculectomy.During the average follow up of 8 months(5 to 12 months),main outcome of measurement of visual acuity,intraocular pressures(IOP),filtering blebs and complications were examined and recoreded.Results(1) No significant differences in visual acuity were found between two groups(P0.05 ).(2) Significant differences in IOPs on one week or 6 months after the surgery were found between the two groups(P0.01).The average post-operative IOP at the 6th months in the observer group was significantly lower(P0.05 ).(3 ) The percentage of functional filtering blebs in the observer group was 86.00%,significantly higher than that of 64.58%in the control group(P0.05).(4) The incidence rate of shallow anterior chamber in the observer group was higher than that of the control group(30.00%vs.10.41%,P0.05),but bleeding in anterior chamber after surgery between the two groups was not significant differences(P0.05).Conclusion The trabeculectomy combined with mitomycin-C has the advantages of preventing post-operative scar formation and achieving better control of post-operative IOP over the conventional trabeculectomy in treating refractory glaucoma.