2008•Chinese Journal of PharmaceuticalsRequires access

Synthesis and Antitumor Activities of Genistein Analogs

Lurong Zhang

Abstract

Twelve genistein analogs were synthesized from p-nitrophenylacetonitrile and phloroglucinol by Friedel-Crafts reaction, cyclization reaction and condensation. Their antitumor activities on MDA-MB-435 cell line and TSU cell line were tested. The results showed that compounds 1b, 1c, 1g and 7 had potent inhibitory effects on TSU cell line and MDA-MB-435 cell line in vitro.

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Key concepts: Phloroglucinol, Chemistry, Genistein, In vitro, Cell culture, Stereochemistry, Biochemistry, Organic chemistry