Application of TACE combined with PVCE and percutaneous radiofrequency ablation in treatment of unresectable hepatocarcinoma

OBJECTIVE: To study the application of transcatheter hepatic artery chemoembolization combined with percutaneous portal vein chemoembolization and percutaneous radiofrequency ablation in treatment of unresectable hepatocarcinoma.METHODS:Totally 48 patients with unresectable hepatocarcinoma treated with TACE/PVCE/PRFA were observed and other 56 patients with TACE alone for control.The hepatic function was tested 7 days after operation and AFP levels was tested 1 month after operation.The AFP level,tumor and portal vein carcinoma embolization decreased rate as well as 1 to 3 years survival rate were studied.RESULTS:There was no significant difference hepatic function between the two groups(P0.05).AFP negativity was 87.5%(28/32)and 59.0%(23/39) one month after operation(χ2=4.662,P=0.031) and the tumor decreased rate was 91.7%(44/48)and 76.8%(43/56) respectively(χ2=4.186,P=0.041),portal vein carcinoma embolization decreased rate was 66.7%(10/15) and 31.6%(6/19) respectively(χ2=4.142,P=0.042).There was a significant difference between the two groups.And 1 to 3 years survival rate were 72.9%(35/48),41.7%(20/48),22.9%(11/48),and 58.9%(33/56),21.4%(12/56),12.5%(7/56) respectively.CONCLUSION:Treatment with TACE/PVCE/PRFA can decrease AFP levels and portal vein carcinoma embolization ratio and prolong 1 to 3 years survival rate.