Effects of massive proteinuria on nephrotic hypoalbuminemia and hyperlipidemia in rats

Objective To further study the effect of massive proteinuria on nephrotic hypoalbuminemia and hyperlipidemia in rats. Methods The changes were observed of serum albumin, cholesterol and triacylglycerol concentrations in rats of group A (perfused with 45 mg of adriamycin per kilogram of kidney weight via bilateral renal arteries), and of group B (perfused with 6.5 mg of adriamycin per kilogram of body weight via the tail vein). Results No significant difference in the level of urine protein was found between groups A and B [(425.3±11.87) mg/d vs (441.93±16.83) mg/d, P0.05]. Serum albumin concentration in group A was higher than in group B [(25 00±1.56) g/L vs (14.03±2.71) g/L,P0.01], serum cholesterol in group A was lower than in group B [(2.67±0.89) mmol/L vs (6.16±0.71) mmol/L, P0.01],and serum triglyceride in group A was lower than in group B [(0.80±0.55) mmol/L vs (5.0±3 29) mmol/L,P0.01]. Conclusion The massive proteinuria may not be the sole cause of hypoalbuminemia and hyperlipidemia in rats with nephrotic syndrome induced by adriamycin.