Application of sufentanil for induction and remifentanil for maintenance as an adjunt to general anestheia in the elderly undergoing abdominal surgery

Objective To evaluate the outcomes of application of sufentanil for induction and remifentanil for maintenance as an adjuvant to general anestheia in the elderly.Methods One hundred patients,aged 65-70 years old,undergoing abdominal surgery were randomly divided into 5 groups with 20 cases each.The depth of general anesthesia with isoflurane inhalation was modulated by BIS.Mean arterial pressure(MAP),Heart rate(HR),bispectral index(BIS),and end tidal isoflurane concentration(CETIso)at the baseline(T0),intubution(T1),1 min(T2)and 5 min after intubution(T3),1 min(T4),5 min(T5)and 10 min after skin incision(T6)and the abdominal exploration(T7)were recorded.Visual analogue scale(VAS)pain score was assessed at 4 h after operation.Consumption of sufentanil in the first postoperative 24 h during PCIA was recorded.Recovery profile and perioperative side effects were also collected.Results The CETIso was higher in group FF than that in groups of SR,FR,SS and RR during anesthesia(P0.05).VAS at 4 h after operation and consumption of analgesics during 24-hours were higher in group RR and FR than those in groups of SR,SS and FF(P0.05 or P0.01).The time of extubation was shorter in groups of SR,FR and RR than those in groups of SS and FF(P0.01).The percentage of restlessness was higher in group RR than that in groups of SR,FR,SS and FF(P0.05).Conclusion Application of sufentanil for induction and remifentanil for maintenance as an adjvant to general anestheia in the elderly has the advantages of stable hemodynamics,early recovery from anesthesia and less adverse effects.