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2006•Zhongguo bijiao yixue zazhiRequires access

Influence of Ningxuewan Granules on the Peripheral Blood Platelets in Mouse Model of Idiopathic Thrombocytopenic Purpura

Liu Yup-bo

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Abstract

Objective To investigate the changes of peripheral blood platelet count and function in the mouse model of idiopathic thrombocytopenic purpura(ITP) and to evaluate the therapeutic effect of a Chinese medicine Ningxuewan(NXW) on those changes.Methods The peripheral platelet count was conducted with an automatic hemocyte analyzer.CD41 and CD61 level was determined by flow cytometry. Results The amount of the peripheral blood platelets in ITP model mice was decreased after injection of antiplatelet serum(APS) and CD41 and CD61 were also decreased as compared with those before injection(P0.001). NXW in high-dose increased the amount of platelets,and elevated the content of CD41 and CD61 to a normal level.Conclusion The platelet count and function are abnormal in mice in the episode of ITP.NXW can increase the amount of peripheral blood platelets and restore the aggregation function of platelets.

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What this paper is about

Objective To investigate the changes of peripheral blood platelet count and function in the mouse model of idiopathic thrombocytopenic purpura(ITP) and to evaluate the therapeutic effect of a Chinese medicine Ningxuewan(NXW) on those changes.Methods The peripheral platelet count was conducted with an automatic hemocyte analyzer.CD41 and CD61 level was determined by flow cytometry. Results The amount of the peripheral blood platelets in ITP model mice was decreased after injection of antiplatelet serum(APS) and CD41 and CD61 were also decreased as compared with those before injection(P0.001). NXW in high-dose increased the amount of platelets,and elevated the content of CD41 and CD61 to a normal level.Conclusion The platelet count and function are abnormal in mice in the episode of ITP.NXW can increase the amount of peripheral blood platelets and restore the aggregation function of platelets.

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Available abstract

Objective To investigate the changes of peripheral blood platelet count and function in the mouse model of idiopathic thrombocytopenic purpura(ITP) and to evaluate the therapeutic effect of a Chinese medicine Ningxuewan(NXW) on those changes.Methods The peripheral platelet count was conducted with an automatic hemocyte analyzer.CD41 and CD61 level was determined by flow cytometry. Results The amount of the peripheral blood platelets in ITP model mice was decreased after injection of antiplatelet serum(APS) and CD41 and CD61 were also decreased as compared with those before injection(P0.001). NXW in high-dose increased the amount of platelets,and elevated the content of CD41 and CD61 to a normal level.Conclusion The platelet count and function are abnormal in mice in the episode of ITP.NXW can increase the amount of peripheral blood platelets and restore the aggregation function of platelets.

Key concepts: Platelet, Thrombocytopenic purpura, Peripheral, Flow cytometry, Peripheral blood, Medicine, Megakaryocyte, Platelet aggregation

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