Influence of Zidian Granule on the Peripheral Blood Platelet in Mouse Model of Idiopathic Thrombocytopenic Purpura

Objective To investigate the changes of the peripheral blood platelet counting and function the mouse model of idiopathic thrombocytopenic purpura (ITP) and to observe the effect of Zidian Granule (ZG). Methods The peripheral platelet counting was conducted with the automatic hemocyte analyzer; CD41 andCD61 level was measured with flow cytometry. Results The amount of the peripheral blood platelet in ITP model mouse was decreased after injection of antiplatelet serum (APS) and CD41 and CD61 were also decreased.(P 0.05 as compared with those before injection). ZG in large dose and prednisone both increased the amount of platelet and ZG at large dose could increase the content of CD41 and CD61 to the normal level. Conclusion The platelet counting and function are abnormal in the episode of ITP; ZG can increase the amount of the peripheral blood platelet and restore the aggregation function of platelet, its- term effect is better than prednisone acetate. 