Prognostic Factors of 103 Patients with Nasopharygeal Carcinoma Treated with Radiotherapy

Objective To analyze the prognostic factors of nasopharyngeal carcinoma treated with radiotherapy.Methods 103 cases of nasopharyngeal carcinoma from January 2000 to December 2002 were selected and treated with radiotherapy to a total dose of 68～80 Gy with 60co γ-ray in 7～8 weeks Univariate analysis of prognostic factors was performed using logrank test and multivariate analysis using Cox model.Results The overall 5-year survival rate was 62.5%,Univariate analysis suggested that the clinical stage,and N stage,T stage,cranial nerve invasion,skull base destruction,the peripheral blood hemoglobin concentration were significant factors for prognosis(P0.05).Multiple factors analysis suggested that T and N stage,cranial nerve invasion,skull base destruction,the peripheral blood hemoglobin concentration were independent prognosis factor.Conclusions The prognosis of patients with cranial nerve palsy and/or skull base invasion and/or bigger cervical tumor and/or the poor peripheral blood hemoglobin concentration is poor.Comprehensive treatment may reduce relapse and metastasis and improve the patient′s survival.