Prognostic Factors of 612 Patients with Nasopharygeal Carcinoma Treated with Radiotherapy

Retrospective analysis of 612 patients with nasopharyngeal careinoma (NPC) treated by radiotherapy from Janury, 1973 to December, 1987 was done. The overall 5-year survival rate was 42.2%.Analsis showed that tumor stage, extra-cavitry extension, cervical node metastasis, cranial nerve involvemnt and dosage were the main signifi-cant prognostic factors. Gradual decrease of 5-year survival rate was seen from stage Ⅰ to Ⅳ,The 5-year survival rate was higher in patients with the tumor limited in nasoharynx than those with tumor extending out of nasopharynx (P＜0.01). The invasion of both anterior and posterior cranial never groups was the poorest. The size, region(ipsilateral of bilateral and upper or lower neck) and movability of the metastatic nodes could influence therapeutic results on NPC. The radiation dose ranged from 65-75Gy/6.57. 5W. Distan metastasis and local recurmnce were the main causes of treatent failure.