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2010•The Journal of Clinical PsychiatryRequires access

Study of efficacy of ziprasidone combined with paroxetine in the treatment of depression with psychotic symptoms

XU Qiu-xi

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Abstract

Objective:To explore the clinical efficacy of ziprasidone combined with paroxetine in the treatment of depression with psychotic symptoms.Method:60 patients of major depression with psychotic symptoms were randomly assigned into the study group and the control one,treated respectively by paroxetine with and without ziprasidone for 6 weeks.The clinical efficacy was evaluated with Hamilton depression scale(HAMD),brief psychiatric rating scale(BPRS) and clinical global impression(CGI),and the side effects was evaluated with treatment emergent symptom scale(TESS) before and after treatments.Results:Scores reduced of the scales of HAMD,BPRS and CGI in the study group were higher than which in the control one,and the incidence of side effects in the two groups had no statistcal difference.Conclusion:Ziprasidone combined with paroxetine is better than paroxetine for treating major depression with psychotic symptoms.

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What this paper is about

Objective:To explore the clinical efficacy of ziprasidone combined with paroxetine in the treatment of depression with psychotic symptoms.Method:60 patients of major depression with psychotic symptoms were randomly assigned into the study group and the control one,treated respectively by paroxetine with and without ziprasidone for 6 weeks.The clinical efficacy was evaluated with Hamilton depression scale(HAMD),brief psychiatric rating scale(BPRS) and clinical global impression(CGI),and the side effects was evaluated with treatment emergent symptom scale(TESS) before and after treatments.Results:Scores reduced of the scales of HAMD,BPRS and CGI in the study group were higher than which in the control one,and the incidence of side effects in the two groups had no statistcal difference.Conclusion:Ziprasidone combined with paroxetine is better than paroxetine for treating major depression with psychotic symptoms.

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Available abstract

Objective:To explore the clinical efficacy of ziprasidone combined with paroxetine in the treatment of depression with psychotic symptoms.Method:60 patients of major depression with psychotic symptoms were randomly assigned into the study group and the control one,treated respectively by paroxetine with and without ziprasidone for 6 weeks.The clinical efficacy was evaluated with Hamilton depression scale(HAMD),brief psychiatric rating scale(BPRS) and clinical global impression(CGI),and the side effects was evaluated with treatment emergent symptom scale(TESS) before and after treatments.Results:Scores reduced of the scales of HAMD,BPRS and CGI in the study group were higher than which in the control one,and the incidence of side effects in the two groups had no statistcal difference.Conclusion:Ziprasidone combined with paroxetine is better than paroxetine for treating major depression with psychotic symptoms.

Key concepts: Paroxetine, Ziprasidone, Hamd, Brief Psychiatric Rating Scale, Depression (economics), Psychology, Clinical Global Impression, Psychiatry

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Study of efficacy of ziprasidone combined with paroxetine in the treatment of depression with psychotic symptoms — Research Paper | ScholarLens