ScholarLens Back to search
2012•Northwest Pharmaceutical JournalRequires access

Determination of total mercury in chemical bulk drugs

Yunqiu Yu

Open publisher page 0 citations

Abstract

Objective To establish a method for the determination of total mercury in chemical bulk drugs by choosing lamivudine as the research object.Methods Mercury was determined by cold vapor atomic absorption spectrometry,using microwave digestion for sample pretreatment.The detection wavelength was 253.7 nm.Results The absorbance and the concentration showed a good linear relationship in the 3.75-18 ng·mL-1 concentration range,and the correlation coefficient was 0.999 6.The recovery of mercury was 96.9%,and the limit of detection was 0.02 μg·g-1.Conclusion The method is specific,sensitive,accurate and rapid,and turns out a universal method for the determination of total mercury in chemical bulk drugs.Simultaneously it could be served as a basis for the drug quality control.

About this research paper

What this paper is about

Objective To establish a method for the determination of total mercury in chemical bulk drugs by choosing lamivudine as the research object.Methods Mercury was determined by cold vapor atomic absorption spectrometry,using microwave digestion for sample pretreatment.The detection wavelength was 253.7 nm.Results The absorbance and the concentration showed a good linear relationship in the 3.75-18 ng·mL-1 concentration range,and the correlation coefficient was 0.999 6.The recovery of mercury was 96.9%,and the limit of detection was 0.02 μg·g-1.Conclusion The method is specific,sensitive,accurate and rapid,and turns out a universal method for the determination of total mercury in chemical bulk drugs.Simultaneously it could be served as a basis for the drug quality control.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To establish a method for the determination of total mercury in chemical bulk drugs by choosing lamivudine as the research object.Methods Mercury was determined by cold vapor atomic absorption spectrometry,using microwave digestion for sample pretreatment.The detection wavelength was 253.7 nm.Results The absorbance and the concentration showed a good linear relationship in the 3.75-18 ng·mL-1 concentration range,and the correlation coefficient was 0.999 6.The recovery of mercury was 96.9%,and the limit of detection was 0.02 μg·g-1.Conclusion The method is specific,sensitive,accurate and rapid,and turns out a universal method for the determination of total mercury in chemical bulk drugs.Simultaneously it could be served as a basis for the drug quality control.

Key concepts: Mercury (programming language), Chemistry, Absorbance, Detection limit, Analytical Chemistry (journal), Microwave digestion, Chromatography, Correlation coefficient

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Determination of total mercury in chemical bulk drugs — Research Paper | ScholarLens