2006•Dalian Yike Daxue xuebaoRequires access
Effect of GBE50 on LPS-induced LOX-1 expression in HUVECs
Peng Qu
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Abstract
[Objective] To investigate the effect of Ginkgo biloba extract 50(GBE50) on LPS-induced LOX-1 expression in HUVECs.[ Metheod] HUVECs were incubated by purified LPS for 24 h.LOX-1 mRNA were measured by RT-PCR,the protein expression of LOX-1 were detected by Western blot.[Results] LPS(1 μg/mL) upregulated LOX-1 mRNA and protein expression,GBE50(40 μg/mL)suppressed LPS-induced LOX-1 mRNA expression(P0.05) and protein expression(P0.05) GBE50(80 μg/mL)and NF-κB inhibitor CAPE both significantly inhibited LOX-1 mRNA expression and protein expression upregulation.[Conclusion] GBE50 may play a role in anti-atherosclerosis by downregulating LOX1 expression.