An investigation of the bone mineral density of patients with type 2 diabetes mellitus and the related factors

Objective To investigate the prevalence and pattern of osteoporosis (OP) in the patients with type 2 diabetes mellitus (DM), and the effect of the related factors. Methods Bone mineral density (BMD) of nondominant forearm, lumbar vertebrae (L 2-4 ) and hip were measured in 80 patients with type 2 DM and in 62 healthy subjects. The correlation between BMD and age, medical history, menopause duration, BMI, FBG, HbAlc, was analysed student's t test, analysis of variance and coefficient of multiple correlation were used. Results BMD decreased in all 80 patients with type 2 DM, of whom 36 (45%) were diagnosed as having OP. BMD signifiantly negatively correlated with age, medical history, menopause duration, FSH and LH ( P 0 05). Conclusion There is a high prevalence of OP in the patients with type 2 DM. Control of blood glucose is beneficial to OP patients. The menopausal female should be given hormone replacement therapy. And, anti OP drugs should be used in DM patients.\;