Isolation rate and drug resistance of Haemophilus during 2004～2005 in our hospital

Objectives To investigate the isolation rate ,enzyme-producing rate and drug resistance of Haemophilus infuenzae and Haemophilus prarinfluenzae during 2004~2005 in our hospital.And to provide a resistance analysis for the guidance of treatment of Haemophilus species infection.Methods Haemophilus from 1695 sputa and throat swabs were isolated and identifed.The β-lactamases producing rate was examined by nitrocefin.Drug resistance of Haemophilus was examined by K-B method.Results Of 226 Haemophilus species,52 were Haemophilus infulenzae,and 174 were Haemophilus parainfulenzae.And 42 were β-lactamases producing.The resistance rate of Ampicillin,Trimethoprim/Sulfa,Ciprofloxacin were 22.1%,74.3% and 57.5%.But the resistance rate of Amoxicillin/Clavulanic,Azithromycin,Cefotaxime,Cefuroxime sodium,Imipem,Rifampin,Aztreonam were under 10%.Conclusions Haemophilus parainfluenzae was the main infection in person with respiratory tract infection in our hospital.Cefotaxine was the most effective antibiotics for Haemophilus species infection.