Actions and clinical observations of Mailuoning Injection(脉络宁注射液 ) on blood rheology of acutely is- chemic cerebrovascular disease

Objective:To observe the clinically curative effects of Mailuoning Injection( ML NI,脉络宁注射 液 ) on treating acutely ischemic cerebrovascular disease( AICVD) and to investigate its active mechanism s. Methods:13 0 patients with AICVD were random ly divided into two groups.The therapeutic group was treated with ML NI 2 0 0 ml+normal saline 5 0 0 ml infused intravenously while the control group treated with venoruton injection0 .4 g+normal saline5 0 0 ml infused intravenously once a day for2 0 days as a therapeutic course to both two groups.The clinically curative effects,the blood rheology,the dynamic CT scanning,and the changes in electrocardiogram were observed.Results:In therapeutic group the clinical cured and m arkedly effective rate ( 81.3 % ) and total effective rate( 96.3 % ) were significantly higher than those( 62 .0 % and80 .0 % ) in control group respectively ( P0 .0 5 and P0 .0 1) ,furtherm ore the total effective rate in dynamic CT scanning obser- vations( 85 .0 % ) was also significantly higher than that( 66.0 % ) in control group( P0 .0 1) .In addition the parameters of blood rheology and so on were significantly im proved in therapeutic group ( P 0 .0 5 or P 0 .0 1) .Conclusions:ML NI possesses the actions on improving the microcirculatory disturbances,increasing the activities of plasminogen and decreasing the fibrinogen etc.Its curative effects on AICVD are obvious.