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2008•Chinese Journal of Hospital PharmacyRequires access

Preparation and in vitro release of etoposide-loaded chitosan microspheres for nasal administration

Jiening Dun

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Abstract

OBJECTIVE To study the preparation and technique and release characteristic of etoposide-loaded chitosan microspheres for the nasal administration.METHODS The chitosan microspheres were prepared through emulsion cross-linking technique using Chitosan as carrier and formaldehyde as cross-linking agent.The diameter,morphology,drug loading and release behavior were observed.RESULTS Microspheres had good sphericity and the average diameter was(46.9±0.7)μm with 78.4% of the microspheres being in the range of 30-70 μm.The accumulative release profile in vitro could be described by Higuichi equation.CONCLUSION The preparation technique is simple and has high entrapment efficiency.Drug release can be applied to nasal administration.

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What this paper is about

OBJECTIVE To study the preparation and technique and release characteristic of etoposide-loaded chitosan microspheres for the nasal administration.METHODS The chitosan microspheres were prepared through emulsion cross-linking technique using Chitosan as carrier and formaldehyde as cross-linking agent.The diameter,morphology,drug loading and release behavior were observed.RESULTS Microspheres had good sphericity and the average diameter was(46.9±0.7)μm with 78.4% of the microspheres being in the range of 30-70 μm.The accumulative release profile in vitro could be described by Higuichi equation.CONCLUSION The preparation technique is simple and has high entrapment efficiency.Drug release can be applied to nasal administration.

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Available abstract

OBJECTIVE To study the preparation and technique and release characteristic of etoposide-loaded chitosan microspheres for the nasal administration.METHODS The chitosan microspheres were prepared through emulsion cross-linking technique using Chitosan as carrier and formaldehyde as cross-linking agent.The diameter,morphology,drug loading and release behavior were observed.RESULTS Microspheres had good sphericity and the average diameter was(46.9±0.7)μm with 78.4% of the microspheres being in the range of 30-70 μm.The accumulative release profile in vitro could be described by Higuichi equation.CONCLUSION The preparation technique is simple and has high entrapment efficiency.Drug release can be applied to nasal administration.

Key concepts: Chitosan, Microsphere, Etoposide, Materials science, Sphericity, Nasal administration, In vitro, Chromatography

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