Clinical analysis of 71 cases with drug-induced liver disease

BACKGROUND To investigate the etiological factors and clinical characteristics of patients with drug-induced liver disease.CASE REPORTSThe medication history,clinical manifestation,laboratory examination,and therapeutic effects were retrospectively analyzed in 71 cases of drug-induced liver disease. There were the 17 cases(23.9%) of traditional chinese medicine,16 cases(22.5%) of antituberculous,13 cases(18.3%) of antibiotics,9 cases(12.7%) of antitumor,7 cases(9.9%) of antipyretic analgesic,4 cases(5.7%) of anti-thyroid,2 cases(2.8%) of central nervous system agents and 3 cases(4.2%) of the others in 71 cases of drug-induced liver disease. The clinical manifestation of drug-induced liver disease was multiplicity and had no particularity. The clinical types of drug-induced liver disease included 30 cases(42.3%) of cholestasis,28 cases(39.4%) of hepatic cells and 13 cases(18.3%) of mixed type. After the medicines inducing liver disease were stopped to use and administrating the hepatoprotection medicine,70 patients (98.6%) were cured with good prognosis,and only one patient(1.4%) progressed to liver cirrhosis.DISCUSSIONMost of the traditional chinese medicine,autituberculous,antibiotics,antitumor medicines are induced the drug-induced liver disease,and its main types are cholestasis,and most of drug-induced liver disease has a good prognosis but individual patients develop serious hepatitis and cirrhosis.