Retrospective analysis of 79 cases of drug-induced liver disease

AIM: To investigate the etiology,clinic manifestation and possible factors affect prognosis. METHODS:A retrospective study of 79 cases of drug induced liver disease was performed in etiology,clinic manifestation,clinic pathologic types,therapy and prognosis. RESULTS:The agents which may cause druginduced liver disease are listed orderly as follows: antitumor agents 15 cases(19 %),antituberculous drugs 10 cases(13 %),antiseptics 10 cases(13 %),immunosuppressive drugs 9 cases((11 %)),non-steroidal anti-inflammatory drugs 9 cases((11 %),) thyroid hormone and antithyroid drugs 6 cases((8 %)),sex and anabolic steroids 4 cases(5 %),Chinese medicine 4 cases(5 %),oral antidiabetic drugs 3 cases(4 %),hypolipidemic agents 3 cases((4 %),) antiepileptics 2 cases(3 %),antipsychosis drug 1 case(1 %),antiviral drug 1 case(1 %),heroin 1 case(1 %),yellow fever vaccine 1 case((1 %)),without clinical manifestation 29 cases((37 %)),anepithymia or vomiting 38 cases(48 %),fever 24 cases(30 %),skin eruption or pruritus 10 cases(13 %),arthralgia 4 cases(5 %),jaundice 30 cases(38 %),hepatomegaly or splenomegaly 12 cases((15 %)),ascites 2 cases(2 %),kaolin stool 1 case((1 %)).Eosinophil increase 11 cases(14 %),with history of drug allergy 10 cases((13 %).) Forty-two cases were liver cell damaged type,8 cases were cholestasis type,29 cases were mixed type. CONCLUSION:The factor affect prognosis of drug induced liver disease is age,old disease and history of drug induced liver disease.The early diagnosis and timing therapy of drug induced liver disease should be highly valued.