The expression of C-erbB-2 in breast invasive ductal carcinoma

Objective To investigate the significance of expression of C-erbB-2 in breast carcinoma.Methods The expression of C-erbB-2 was detected by S-P immunohistochemical technique in 161 cases of breast invasive ductal carcinoma.Results The expressing rates of C-erbB-2 were 27.43% and 31.25% in the age group above 50 and below 50 years respectively,and there was no significant difference between the two age groups(P0.05).The positive expressing rates of C-erbB-2 were 19.05%,24.21% and 42.22% in breast carcinoma tissues at grade 1,2 and 3 respectively,which was higher in grade 3 than that in other two groups(P0.05).C-erbB-2 expressing rates in patients without and with low frequency of lymph node metastases were 20.43%,29.41% respectively,which was significantly higher than that(44.0%) in high frequency of lymph node metastases(P0.05).Conclusion The over-expression of C-erbB-2 was closely related with a high histological grade and high frequency of lymph node metastases.C-erbB-2 may be a valuable prognostic indicator for breast invasive ductal carcinoma.