Therapeutic efficacy of Acitretin in treatment of patients with palmoplantar pustulosis

Objective: To explore the therapeutic efficacy of Acitretin in the treatment of patients with palmoplantar pustulosis.Methods: The patients with palmoplantar pustulosis were divided into group A(27 cases) and group B(26 cases).27 patients in group A were treated with Acitretin which was administered 20-30 mg per day for 2 weeks,then adjusted the dosage according to the response for another 8 weeks.26 patients in group B were treated with Doxycycline 200 mg per day for 2 weeks,then tapered to 100 mg per day according to the response for another 8 weeks,Halometasone Cream was used in two groups.The efficacy was evaluated after treating 2,4,8 weeks.Results: After treatment of 2,4,8 weeks,in the group A,the effective rates were 60.0%,80.0% and 92.0% respectively,and were 29.1%,41.7%,54.2% in the group B.There were significant differences on the effective rates in two groups(P=0.030,0.006,0.006 respectively).Conclusion: The administration of Acitretin is effective in the treatment of palmoplantar pustulosis,it′s worthy of clinical use.