2012•Xinxueguan kangfu yixue zazhiRequires access
Changes and its significance of serum interleukin-6 and interleukin-10 in AMI patients after percutaneous coronary intervention
Zhao Xiao-hui
Open publisher page 2 citations
Abstract
Objective:To explore changes of interleukin(IL)-6 and IL-10 concentration and its clinical significance in patients with acute myocardial infarction(AMI) after emergency percutaneous coronary intervention(PCI).Methods:A total of 60 AMI patients undergoing emergency PCI(AMI group) and 30 subjects with normal coronary angiography(normal control group) were enrolled in the study.Enzyme linked immunosorbent assay(ELISA) was used to measure serum concentrations of IL-6 and IL-10 in AMI patients on first and seventh day after PCI,and the results were compared with those of normal control group.Results: Compared with normal control group,there were significant increase in serum levels of IL-6 [(110.34±26.01) pg ml vs.(156.97±68.58) pg ml],IL-10 [(18.21±4.0) ng ml vs.(19.94±10.01) ng ml]and ratio of IL-6 IL-10 [(6.73±2.04) vs.(10.99±8.24)]in AMI group on seventh day after PCI(P0.05 all).The IL-6 level was positively correlated with that of IL-10(r=0.44,P0.05).Conclusion: Levels of interleukin-6 and interleukin-10 increase after acute myocardial infarction,they may participate in occurrence and development of acute myocardial infarction.