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Advances in CYP3A4 over-expressed cell models and their application to drug metabolism research

Chuan‐jiang Zhu

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Abstract

Cytochrome P450 3A4(CYP3A4),one of cytochrome P450 enzymes family,is involved in metabolism and interaction of various compounds,and a key target for drug screening and metabolism research.This article tries to review the development of CYP3A4 over-expressed cellular models,and their application in drug metabolism and drug-drug interaction in chronological sequence.The aim is to introduce the valuable models to research on new drugs.

About this research paper

What this paper is about

Cytochrome P450 3A4(CYP3A4),one of cytochrome P450 enzymes family,is involved in metabolism and interaction of various compounds,and a key target for drug screening and metabolism research.This article tries to review the development of CYP3A4 over-expressed cellular models,and their application in drug metabolism and drug-drug interaction in chronological sequence.The aim is to introduce the valuable models to research on new drugs.

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OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Cytochrome P450 3A4(CYP3A4),one of cytochrome P450 enzymes family,is involved in metabolism and interaction of various compounds,and a key target for drug screening and metabolism research.This article tries to review the development of CYP3A4 over-expressed cellular models,and their application in drug metabolism and drug-drug interaction in chronological sequence.The aim is to introduce the valuable models to research on new drugs.

Key concepts: CYP3A4, Drug metabolism, Cytochrome P450, Drug, Computational biology, Drug development, Metabolism, Pharmacology

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