CYP450 induction based drug-drug interaction and evaluation methodology

Drug discovery and development is an expensive process with a high attrition rate.Cytochrome P450(CYP) induction and inhibition mediated drug-drug interaction of drug candidates serves as one of the reasons for such attrition.Consequently a great effort is paid to identify those compounds that influence pharmacokinetic parameters of other drugs,which may lead to drug-drug interactions.CYP plays a central role in metabolism and biosynthesis of a wide range of exogenous and endogenous compounds.CYP induction mediated drug-drug interactions may result in an increased metabolic clearance for coadministrated drugs,and subsequently affect their effectiveness and safety.Assessment of CYP induction potential for drug candidates has become an integral part of new drug discovery and development.This article reviews the current understanding on CYP induction mediated drug-drug interaction and its clinical implications,along with the in vitro and in vivo methodologies for assessment of the induction potential of new drug candidates.