The expression and significance of survivin gene in cervical cancer

Objective To explore the relationship between the expression of survivin gene and clinical pathological factors in cervical cancer and study the clinical singnificance of survivin gene. Methods Immunohistochemical S-P method was used to determine the expressioof survivin gene in 41 cervical cancer tissues and 17 CIN cervical tissues and 10 normal cervical tissues. The relationship between the expression and clinical pathology was analyzed. Results The positive rate of survivin gene in cervical cancer was singnificantly higher than that in CIN and normal cervical tissues (P0.05). Survivin-positive cervical cancer patients had significantly shorter median survivial times compared with survivin-negative cervical cancer patients (P0.05). There was no relationship with clinical stage and tumor grade or pathological type. Conclusion The increasing positive expression of survivin gene may be closely related to the oneset of cervical cancer and may predict poor prognosis.