Efficacy Analysis of Early Mild Hypothermia Combined with Post-Hyperbaric Oxygen Treatment in Severe Traumatic Brain Injury

Objective: To evaluate the clinical effects of early hypothermia combined with post-hyperbaric oxygen treatment in severe traumatic brain injury. Methods: All 157 patients with acute severe traumatic brain injury were divided into early hypothermia therapy group (mild hypothermia group, n =54), early hypothermia combined with post-hyperbaric oxygen group (mild hypothermia and hyperbaric oxygen group, n =48) and the conventional therapy group ( n =55) according to the inpatient order. The efficacy was determined by Glasgow score (GOS) 3 months after treatment. The activities of daily living (ADL) were evaluated after treatment in patients, addition to the plant survival and death patients. Results: There were significant differences in mortality rates of mild hypothermia plus hyperbaric oxygen group and conventional treatment group ( P 0.05). There were significant differences in good recovery rates between three groups ( P 0.05), and the highest good recovery rate was in mild hypothermia and hyperbaric oxygen group. There was significant difference in ADL between mild hypothermia group, mild hypothermia plus hyperbaric oxygen group and conventional treatment group ( P 0.001), and between mild hypothermia group and mild hypothermia plus hyperbaric oxygen group ( P 0.001). Conclusion: The early application of mild hypothermia can reduce the mortality in patients with severe traumatic brain injury. The early hypothermia combined with post-hyperbaric oxygen treatment can improve the good recovery rate. The combination therapy is a better treatment for the traumatic brain injury.