Effects of methylprednisolone on brain tissue NOS after brain trauma of rats

Objective To observe the role of methylprednisolone by change of NOS level in rat brain trauma tissue. Methods 45 rats were divided into three groups: treated group (20 rats, were extradurally hit from the bone window and then treated with methylprednisolone 30mg/kg), control group (20 rats, treated with physiologic saline after hitting) and normal group (only expose extradural without hitting and injection). The levels of NOS were measured at different points of time after hitting. Results NOS level in rat cerebral cortex was higher than that in the control group 1 hour after injury, and began to reduce 6 hour after trauma and dropped to the basic level post-traumatic 12-24 hour. The levels of NSO in methylprednisolone treatment group were obviously lower than that in the injured group post-traumatic 1 hour and 6 hour. Conclusion Methylprednisolone is effective for head injury.