Effects of methylprednisolone on brain tissue ICAM-1 after brain trauma of rats

Objective To observe the effects of methylprednisolone on the change of ICAM-1 level in brain trauma tissue of rat.Methods Fifty-five rat brain traumatic models were made by frontoparictal bone window plasty with extradural hitting.The rats were divided to three groups: treated group (treated with methylprednisolone,30 mg/kg after hitting),contral group (treated with physiologic saline after hitting) and normal group (only expose extradural without hitting and injection).The levels of ICAM-1 were measured at different time points after hitting.Results ICAM-1 level in rat cerebral cortes was higher in treated group than that in the contrl group post-traumatic 6 h,reached the peak post-traumatic 48 h and dropped to the basic level post-traumatic 72 h.The levels of ICAM-1 in treated group was obviously lower than in control group post-traumatic 6-48 h.Conclusion Methylprednisolone could pretect the traumatic neurons by inhibiting the activity of ICAM-1 which was increased in the injured brain tissues after brain injury.