Study on the effectiveness of auxiliary therapy with liuweinengxiaojiaonang and deanxit in patients of non-erosive reflux disease(NERD) who did not respond to proton pump inhibitor

Objective To observe the effectiveness of auxiliary therapy with liuweinengxiaojiaonang and Deanxit in patients of non-erosive reflux disease(NERD)who did not respond to proton pump inhibitor.Methods 87 NERD patients were randomly divided into two groups:the treatment group(44) and control group (43).Patients in control group were given with lansoprazole.Patients in the treatment group were given the same drugs plus liuweinengxiaojiaonang and deanxit.Before the treatment,clinical symptoms as heartburn,chestpain,acid reflux were observed respectively,psychological assessments were performed in two groups using the hamilton depression scale(HAMD-17).All of 87 NERD patients psychological assessments of HAMD-17 showed≥18 scores.The clinical outcomes of two groups were compared after 4 weeks.Results The effective rate in treatment group was 88.6%,while that was 65.1% in control group(P0.05).The HAMD-17 assessments showed that treatment group had lower scores than the control with a statistically significant difference (P0.01).There was no significant difference in the side effects between two groups(P0.05).Conclusion NERD patients who did not respond to proton pump inhibitor were more likely co-morbid with psychological disorders and the depression score was higher.Auxiliary therapy with liuweinengxiaojiaonang and deanxit are more effective for treating NERD patients who did not respond to proton pump inhibitor.