Significance of Mcl-1 expressions in gastric cancer by tissue microarray

Objective To study the expression of Mcl-1 in gastric cancer and its clinical significance.Methods Tissue microarrays containing gastric cancer tissue(n=148) and gastric normal tissue(n=20) were prepared and the expression of Mcl-1 was detected by immunohistochemistry.Results Immunohistochemistry showed that gastric cancer tissues and gastric normal tissue both had the expression of Mcl-1 protein,located in the cytoplasm,pale yellow to dark brown color.In gastric cancer tissues and gastric normal tissue Mcl-1 protein expression rates were 83.78%(124/148),60.00%(12/20),respectively.The difference was statistically significant(χ2 = 6.464,P=0.011).In gastric cancer tissues,the expression of Mcl-1 protein with lower degree of tumor differentiation was enhanced,and was associated with lymph node metastasis,but not associated with the patient's age,sex,tumor size,and the tumor infiltration depth(P0.05).Conclusion The Mcl-1 protein expression of the gastric cancer tissues is heightened,which is closely related with the development of gastric cancer,its differentiation degree,lymph node metastasis.