Control study of escitalopram and amitriptyline in treatment of depression

Objective: To compare the clinical efficacy and safety of escitalopram and amitriptyline in treatment of depression.Methods: Randomly divided fifty patients into two groups,the study group included 25 cases and took escitalopram orally,the control group included 25 cases and took amitriptyline orally,who were all obseved 6 weeks.Before and after 1,2,4,6 weeks of treatment,evaluation of clincal effects with Hamilton's depression scale(HAMD) and clinical global impression(CGI),evaluation of side effects with Asberg.Results: On the sixth weekend,the obvious effect rate was 96% in the study group,but that was 92% in the control group,which had no significant difference(P0.05).The total scores of Asberg in the study group were significant lower than that in the the control group(P0.01).Conclusion: On treating the patients with depression,the effects of escitalopram is equvalent with amitriptyline,but escitalopram is better than amitripty-line in safety and the compliance.