Application of dexmedetomidine as an adjunct in general anesthesia for patients undergoing gynecological laparoscopy

Objective To study the effect of dexmedetomidine as an adjunct in general anesthesia for patients undergoing gynecological laparoscopy. Methods Sixty ASA Ⅰ ~ Ⅱ patients undergoing gynecological laparoscopy were randomly assigned into two groups: dexmedetomidine group( group D) and control group( group C) with 30 each. Dexmedetomidine was infused with a bolus of 0. 5 μg· kg- 1( infused more than 10 min) before anesthesia induction in group D,followed by 0. 4 μg·kg- 1·h- 1continuous infusion. 0. 9% sodium chloride was infused in the same way in control group. MAP and HR were recorded at the time points of pre-administration of dexmedetomidine( T0),immediately after intubation( T1),after incision( T2),10 min after aeroperitioneum( T3),immediately after extubation( T4). The following variables were also recorded: surgery time,anesthesia time,emergence and extubation time,cough response and restlessness rate. Results There were no significant differences between two groups in surgery time,anesthesia time,emergence time and extubation time. MAP,HR in group D were lower than those in control group immediately after intubation( T1), after incision( T2),10min after aeroperitioneum( T3),immediately after extubation( T4)( P 0. 05). Compared with those at T0, MAP and HR were significantly increased at T1 ~ 4in group C( P 0. 05). The rates of cough response and restlessness in group D were lower than those in control group( P 0. 05). Conclusions Dexmedetomidine infused with a bolus of 0. 5 μg·kg- 1( infused more than 10min) before anesthesia induction,followed by 0. 4 μg·kg- 1· h- 1continuous infusion can effectively diminish the patients' fluctuation of hemodynamics and reduce the rate of patients' cough response and recovery restlessness. It is beneficial to general anesthesia in patients undergoing gynecological laparoscopy.