The effect of postoperative immune-enhanced enteral nutrition onimmune function in patients with total gastrectomy

Objective: To elucidate the effect of postoperative immune-enhanced enteral nutrition support on immune function in patients with total gastrectomy.Methods: Fifty-two gastric cancer patients with tatal gastrectomy were randomly divided into two groups: enteral nutrition group(EN group,n=26) and immune-enhanced enteral nutrition group(experiment group,n=26).The same quantity of calorie and nitrogen was provided from the first day after surgery for both groups.Patients in EN group received conventional enteral nutrition support with Nutrison,and patients in experiment group received immune-enhanced enteral nutrition support with Stresson for 7 days.The levels of IgG,IgA,IgM,CD3,CD4,CD8,CD4/CD8 were measured preoperatively and on day 1 and 8 after operation.Results: All the levels of immune function were decreased on postoperative day 1 in two groups.The levels of IgG,IgA,IgM,CD3,CD4 and CD4/CD8 were increased in both groups on postoperative day 8,and there was significant difference between two group(P0.05). Conclusion: Early postoperative immune-enhanced enteral nutrition support could improve the immune function of gastric cancer patients with total gastrectomy,it works better than conventional enteral nutrition.