Expression and clinical significance of CD133 and B7-H4 in non-small cell lung cancer

Objective To study the expression and significance of CD133 and B7-H4 in human non-small cell lung cancer (NSCLC).Methods The expressions of CD133 and B7-H4 were detected by flow cytometry in pleural fluid from NSCLC patients,which were detected with immunohistochemistry in 103 NSCLC specimens,25 tumor-adjacent normal tissues,and 24 benign inflammatory lesion tissues.Results CD133 and B7-H4 expressed in pleural fluid of NSCLC cases.The expression rate of CD133 was 49.51%(51/103) and that of B7-H4 was 66.99%(69/103) in NSCLC specimens,which were all significantly higher than those in tumor-adjacent normal tissues and in benign lesions(P0.01).CD133 expression was related to the differentiation degree of NSCLC,and correlated with B7-H4 expression(P0.01).CD133 positive expression was associated with poor prognosis of NSCLC patients.Conclusion CD133 and B7-H4 are overexpressed in NSCLC and might induce the process of tumor evading host immune surveillance.CD133 might be an independent risk factor for NSCLC.