The effect of adefovir dipivoxil combined with bicyclol in the treatment of chronic hepatitis B

Objective To analyze the effect of adefovir dipivoxil combined with bicyclol in the treatment of chronic viral hepatitis B(CHB).Methods Sixty patients with CHB were randomly divided into two groups: the treatment group(30 cases) and the control group(30 cases).Thirty patients in the treatment group orally received adefovir dipivoxil(10 mg,once a day) and bicyclol(25 mg,two times a day) for 48 weeks.Thirty control subjects received adefovir dipivoxil(10 mg,once a day) orally for 48 weeks.The level of serum aminotransferace(ALT),blood urea nitrogen(BUN) and creatinine(Cr) of patients with pre-treatments,24 weeks post-treatments and 48 weeks post-treatments between the two groups were compared with t-test.The ALT level normalization rates and HBV DNA negative rates of patients with 24 weeks post-treatments and 48 weeks post-treatments between the two groups were compared with χ2-test.Results The ALT level of patients in the treatment group 24 weeks post-treatment were lower than that of the control group [(145.47 ± 61.95) U / L vs(189.09 ± 52.02) U / L].And the difference was statistically significant(t = 2.953,P = 0.005).Twenty-four weeks after treatment,the ALT level of patients in the treatment group was lower than that in the control group,while the ALT level normalization rates in the treatment group was higher than that in the control group[43.3%(13 /30) vs 80.0%(24 /30) ].And the differences were both statistically significant(t = 2.953,P = 0.005; χ2= 7.051,P = 0.008).The differences of HBV DNA negative rates of the two groups was not statistically significant 24 weeks post-treatments.Forty-eight weeks after treatment,the ALT level of patients in the treatment group was lower than that in the control group[(60.03 ± 29.89) U / L vs(91.38 ± 48.98) U / L],while the ALT level normalization rates and HBV DNA negative rates of patients in the treatment group was higher than that in the control group [73.3%(22/30) vs 53.3%(16/30),63.3%(19/30) vs 90.0%(27/30) ].And the differences were all statistically significant(t = 2.515,P = 0.015; χ2= 4.565,P = 0.033; χ2= 4.800,P = 0.029).The differences of the BUN level and Cr level of the two groups 24 or 48 weeks post-treatments were not statistically significant compared with that of pre-treatments.The two groups of patients were not found significant adverse reactions during treatment.Conclusion The treatment of adefovir dipivoxil combined with Bicyclol would get better biochemical response and virological responseis,and has good security.