Effect analysis of Entecavir combined with Oxymatrine on patients with HBeAg positive chronic hepatitis B

Objective To observe the effects of Entecavir combined with oxymatrine on patients with HBeAg-positive chronic hepatitis B(CHB).Methods 120 cases were enrolled with HBeAg-positive CHB.They were randomly divided into treatment group(60 cases) and control group(60 cases),patients in treatment group daily received Entecavir 0.5 mg,Oxymatrine tablets 0.6 g and those in control group daily doses Entecavir 0.5 mg.Therapeutic effects were observed at 12,24,48 weeks after medication.Results ① The ALT normalization rates of control group and treatment group after 12,24,48 weeks were 60.00%,75.00%,91.67% and 48.33%,60.55%,76.67%,respectively,and in the 12,24 weeks,no statistically difference was found between two groups(P 0.05),while in 48 weeks there was difference between them(P 0.05).② The HBV-DNA negative conversion rates in control group and treatment group after 12,24,48 weeks were 40.00%,61.67%,81.67% and 38.33%,51.67%,61.67%,respectively,and in the 12,24 weeks,no statistically significant difference was found between two groups(P 0.05),while in 48 weeks there was difference between them(P 0.05).③The HBeAg / HBeAb seroconversion rate of control group and treatment group in 12 weeks and 24 weeks were respectively 11.67%,18.33% and 10.00%,15.00%(P 0.05),while in 48 weeks,respectively 35.00% and 18.33%.The differences were also statistically significant(P 0.05).Conclusion The combination of Entecavir and Oxymatrine can significantly enhance the effectiveness of antiviral therapy in the treatment of CHB.