The clinical efficacy of the partial spleen artery embolization on the treatment of hypersplenism in 90 hepatic cirrhosis patients

Objective To observe the clinical curative efficacy of the partial spleen artery embolization( PSE) on the treatment of hypersplenism with hepatic cirrhosis. Methods 90 cases with hepatic cirrhosis and hypersplenism treated by PSE were retrospectively analyzed. The changes of blood routine,spleen size,portal vein diameter,the hemodynamics of portal vein and splenic vein,and the incidence of complications were observed and compared between preoperative and postoperative PSE from one to four years.These parameters were detected by biochemistry test and Color Duplex Dopper. Results At clinical observation for these patients,these parameters were improved to different extent compared with pre-operation. White blood cell and platelet count in PSE post-operation were significantly increased( P 0. 05). Spleen gradually diminished after 3 months of past-operation and there had statistical significance in 6 months( P 0. 01). Portal vein diameter also reduced. Moreover,the hemodynamic changes of portal vein and splenic vein were improved obviously. Additionally,some complications were occurred including left epigastric pain and fever in 83 cases,ascites /pleural effusion in 10 cases and left-side pneumonia in 5 cases. Conclusion PSE could improve hypersplenic symptoms significantly,reduce the portal vein pressure,decrease the risk of gastrointestinal bleeding with stable long term effect,suggesting PSE is an ideal operative mode with less trauma,safety and effectivity to treat hyperslpenism with hepatic cirrhosis.