Effects of Vitamin B and GSH on rats fatty liver

Objective To study the effects of complex vitamin B,GSH on the fatty liver rats. Methods 50 male Wistar rats were allocated to normal control group(NC),model control group(TC),intervention of Co VB(T-VB),intervention of GSH(T-glu),intervention of Co VB and GSH(T-glu+B),respectively.Except NC,other groups were treated with Carbon Tetrachloride(CCl4),high fat diet and alcohol water solution to produce fatty liver model.At the same time,experimental groups were drenched Co VB or(and) GSH,respectively.NC and TC group was drenched physiological salt solution for 28 days.The MDA content and SOD activity in liver were measured.Results Compared with NC group,TC group rats liver MDA content were increased,but SOD activity was decreased(P0.05);Compared with TC group,experiment groups liver MDA content were decreased,but SOD activity were increased(P0.05).Conclusions Co VB and GSH can protect rats' fatty liver by antioxidation.