Therapeutic Effects of Fuzheng Xiezhuo Baoshen Decoction on Chronic Renal Failure in Rats

Objective:To study the possible mechanism of Fuzheng Xiezhuo Baoshen(FZXZBS)Decoction's therapeutic effects on chronic renal failure(CRF) in rats.Method: Ten rats were normal in control group(N),which were randomly selected from the total 50 male SD rats,the other 40 rats were established chronic renal failure model by gavaging with adenine.And then the model rats were randomly divided into four groups:model group(M),Losartan Potassium group(LP,5 mg·kg-1),FZXZBS decoction large and small dose groups(37.6,18.8 g·kg-1)with 10 rats per group.Finally the rats were sacrificed after 30 days treatment.Blood sample and kidney tissue were reserved.The kidney index,blood biochemical indices,pathological changes and expression of transforming growth factor-β1(TGF-β1)in renal tissue were observed.Result:Compared with M,the levels of Scr,BUN in L and S were significantly decreased(P0.01),and the level of BUN in L was remarkably lower than that in LP(P0.05).The kidney index in L was obviously lower than those in M and LP(P0.01),and S was significantly lower than those in M(P0.01)and LP(P0.05)respectively.The expression of TGF-β1 in renal tissue in L was remarkably lower than those in M and LP(P0.01),and even lower than that in S(P0.05).Conclusion: FZXZBS Decoction has a preventive and therapeutic effect on CRF.Reducing of the expressions of TGF-β1 in renal tissue may be one of the mechanisms to inhibit the progress of CRF.