2012•Laboratory Medicine and ClinicRequires access
The clinical application of combined detection of four tumor markers in patients with cervical squamous cell carcinoma
Yansong Chen
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Abstract
Objective To investigate the value of the serum levels of squamous cell carcinoma(SCC),cytokeratin-19-fragments(CYFRA21-1),tissue polypeptide specific antigen(TPS) and carcinombryonic antigen(CEA) in patients with cervical squamous cell carcinoma.Methods SCC were measured by Chemiluminescence immunoassay,CYFRA21-1 and CEA were measured by electro-chemiluminescence immunoassay,and TPS was measured by enzyme-linked immunosorbent assay.Levels of SCC,CyFRA21-1,TPS,CEA30 in healthy females,13 patients with cervical inteaepithelial neoplasia and 52 patients with cervical squamous cell carcinoma were detected,and analyzed by SPSS software.Results The levels and positive rates of SCC,CYFRA21-1 and TPS in patients with cervical squamous cell carcinoma were significantly higher than those of health femals and cervical inteaepithelial neoplasia(P0.05).The sensitivity,specivity and accuraty were increaed with combination of SCC+CYFRA21-1+CEA+TPS.Conclusion There is sepecifically clinical applicated valuation of combined detection of the four tumor markers for diagnosis of cervical squamous cell carcinoma.