Correlation of Androgen Receptor Expression to Activity of Cell Proliferation and Clinicopathology in Meningiomas

Objective To explore the correlation of androgen receptor(AR) expression to the activity of cell proliferation and clinicopathology in meningiomas.Methods The expressions of AR and proliferating cell nuclear antigen(PCNA) were determined by SABC immunohistochemical method in 50 cases of meningioma tissues.Correlation between AR expression with clinicopathological characteristics was studied.Results The positive rates of AR expression were 29.2%(8/24) in benign meningiomas,56.3%(9/16) in atypical meningiomas,80.0%(8/10)in malignant meningiomas,respectively.Malignant meningiomas had a significantly higher AR expression rate compared with atypical meningiomas and benign meningiomas (P0.05).AR positive meningiomas had higher PCNA labeling index(LI) compared with AR negative meningiomas (P0.01).The expression of AR in meningioma tissues was significantly related with PCNA.Conclusion The overexpressions of AR in meningiomas is related to high rate of cell proliferation and histological grated and may play an important role in the development of meningiomas.